A selective defect in tissue factor mRNA expression in monocytes from AIDS patients.

J L Lathey; J M Agosti; J A Nelson; L Corey; S A Gregory; J H Morrissey; T S Edgington; M B Oldstone

doi:10.1016/0090-1229(90)90001-7

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A selective defect in tissue factor mRNA expression in monocytes from AIDS patients.

J L Lathey·J M Agosti·J A Nelson·L Corey·S A Gregory·J H Morrissey·T S Edgington·M B Oldstone

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Abstract

Expression of tumor necrosis factor (TNF alpha), tissue factor (TF), and interleukin 1-beta (IL-1 beta) mRNA was evaluated in monocytes isolated from patients infected with human immunodeficiency virus (HIV). There was a significant depression (66%) of the induced level of TF mRNA expression in response to lipopolysaccharide. Conversely, the response of TNF alpha and IL-1 beta, following LPS induction, was "normal." TF mRNA reduction was also observed to a lesser degree in AIDS-related complex patients (20%) but not in asymptomatic seropositives. TF is necessary for initiation of the coagulation protease cascade, leading to thrombin production and fibrin deposition, which play a role in inflammatory responses. Its selective reduction may be a factor in the diminished resistance to secondary infections observed in AIDS. Further, since the TF defect increases as patients progress toward AIDS, it may serve as a marker for disease progression.

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Acquired Immunodeficiency Syndrome Adult Blood Coagulation Humans Hypersensitivity, Delayed Interleukin-1 Lipopolysaccharides Male Monocytes RNA, Messenger Thromboplastin Tumor Necrosis Factor-alpha Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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J L Lathey, J M Agosti, J A Nelson, L Corey, S A Gregory, J H Morrissey, T S Edgington, M B Oldstone. 1990. A selective defect in tissue factor mRNA expression in monocytes from AIDS patients.. https://doi.org/10.1016/0090-1229(90)90001-7

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