Differences in sensitivity to neuroleptic blockade: medial forebrain bundle versus frontal cortex self-stimulation.

D Corbett

doi:10.1016/0166-4328(90)90163-9

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Differences in sensitivity to neuroleptic blockade: medial forebrain bundle versus frontal cortex self-stimulation.

D Corbett

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Abstract

The effects of systemic injections of the dopamine receptor antagonist, cis-flupenthixol were tested on intracranial self-stimulation at electrode sites in the medial forebrain bundle and the medial prefrontal cortex. Changes in the reward effectiveness of the brain stimulation were assessed using a curve-shift paradigm. Low to moderate doses of cis-flupenthixol (0.05, 0.1 and 0.15 mg/kg) consistently produced larger upward shifts in the rate-frequency function for medial forebrain bundle than for medial prefrontal self-stimulation. At the highest doses of cis-flupenthixol (0.15 and 0.2 mg/kg), some of the medial forebrain bundle rats failed to respond, whereas all medial prefrontal rats responded at these doses. These results demonstrate that medial forebrain bundle self-stimulation is much more dependent on dopamine systems than is prefrontal cortex self-stimulation.

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Animals Arousal Dopamine Dose-Response Relationship, Drug Electric Stimulation Flupenthixol Frontal Lobe Male Medial Forebrain Bundle Rats Rats, Inbred Strains Receptors, Dopamine Self Stimulation Thioxanthenes Journal Article Research Support, Non-U.S. Gov't

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D Corbett. 1990-01-01. Differences in sensitivity to neuroleptic blockade: medial forebrain bundle versus frontal cortex self-stimulation.. https://doi.org/10.1016/0166-4328(90)90163-9

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