Thermal exchanges during sleep in anhidrotic ectodermal dysplasia.

Abstract

Anhidrotic ectodermal dysplasia is a congenital syndrome characterized by the absence of sweat glands. A sweating test was performed on such a patient and proved his inability to sweat. Thermal exchanges during night sleep were then measured in this patient and compared with data obtained from a healthy control subject. Ambient conditions were as follows: dry bulb temperature 32.2 degrees C, relative humidity 30%-40%, wind speed 0.7 m.s-1. Polysomnographic recordings showed normal sleep patterns in both subjects, but a "first night effect" in the patient. Rectal (Tre) and mean skin (Tsk) temperatures and loss of mass were monitored continuously throughout the 8-h sleep recording. Loss of mass averaged 34.1 g.h-1 in the patient vs 78.1 g.h-1 in the control subject. No relationship with sleep stages was observed in the patient, in contrast to the control subject who experienced a decrease in evaporation during rapid eye movement sleep. Body temperatures varied little in the patient, but decreased until the 6th h of sleep in the control subject. On two occasions there was a 0.3 degrees C fall in the Tre of the patient during two slow wave sleep (SWS) phases, while Tsk and loss of mass did not change. As thermolytic processes had not varied on these two occasions, it was concluded that the fall in Tre indicated a concomitant decrease in metabolic heat production, in agreement with the assumption that SWS represented a state of energy conservation.