Carcinogenicity studies with deltamethrin in mice and rats.

J R Cabral; D Galendo; M Laval; N Lyandrat

doi:10.1016/0304-3835(90)90151-m

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Carcinogenicity studies with deltamethrin in mice and rats.

J R Cabral·D Galendo·M Laval·N Lyandrat

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Abstract

The pesticide Deltamethrin, a synthetic pyrethroid, was studied for carcinogenicity in long-term experiments in mice and rats. Mice were given Deltamethrin by gavage in arachis oil at 0, 1, 4 or 8 mg/kg body wt for 2 years. A group of untreated controls was also available. Rats received 0, 3 or 6 mg/kg body wt. Deltamethrin in arachis oil for 2 years. In mice, an increased incidence of lymphomas was observed in the groups receiving 1 and 4 mg/kg body wt., but not in the group treated with 8 mg/kg body wt. Deltamethrin. In rats, an increased incidence of thyroid tumours was noted, but, no clear dose-response relationship was shown. Deltamethrin does not appear to be carcinogenic in mice or rats, but further studies are needed on the group of compounds to which this substance belongs.

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Adenoma Animals Carcinogenicity Tests Carcinogens Dose-Response Relationship, Drug Female Insecticides Liver Neoplasms, Experimental Lung Neoplasms Lymphoma Male Mice Mice, Inbred C57BL Nitriles Pyrethrins Rats Thyroid Neoplasms Journal Article

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J R Cabral, D Galendo, M Laval, N Lyandrat. 1990. Carcinogenicity studies with deltamethrin in mice and rats.. https://doi.org/10.1016/0304-3835(90)90151-m

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