SIMFIT: a microcomputer software-toolkit for modelistic studies in biochemistry.

H G Holzhütter; A Colosimo

doi:10.1093/bioinformatics/6.1.23

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SIMFIT: a microcomputer software-toolkit for modelistic studies in biochemistry.

H G Holzhütter·A Colosimo

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Abstract

A software package suitable for personal computers and designed to handle simulation and fitting problems related to the study of biomolecules under pre-steady and steady state conditions is presented, and its overall architecture as well as the implemented algorithms illustrated. The peculiar features of the package are: (i) integrated capability of simulating dynamic models and fitting to them experimental data; (ii) handling of stiff problems; (iii) free use of algebraic as well as differential equations; (iv) objective comparison of models of different complexity. The above features are discussed through a number of examples taken from the direct experience of the authors in enzyme kinetics and ligand binding.

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Biochemical Phenomena Biochemistry Computer Simulation Enzymes Kinetics Ligands Microcomputers Models, Chemical Software Journal Article Research Support, Non-U.S. Gov't

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H G Holzhütter, A Colosimo. 1990. SIMFIT: a microcomputer software-toolkit for modelistic studies in biochemistry.. https://doi.org/10.1093/bioinformatics%2F6.1.23

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