Morphine presynaptically inhibits a ganglionic cholinergic synapse.

J C Bornstein; H L Fields

doi:10.1016/0304-3940(79)91532-5

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Morphine presynaptically inhibits a ganglionic cholinergic synapse.

J C Bornstein·H L Fields

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Abstract

The effects of morphine on synaptic transmission through the inferior mesenteric ganglion (IMG) were studied using intracellular recording techniques. Morphine produced a reversible, dose-dependent reduction in the quantal content of the synaptic potentials with little or no effect on quantal size or the properties of the ganglion cells. This effect of morphine was antagonized by naloxone suggesting the presence of specific preganglionic opiate receptors.

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Animals Depression, Chemical Dose-Response Relationship, Drug Evoked Potentials Ganglia, Sympathetic Guinea Pigs Morphine Naloxone Synapses Synaptic Transmission Journal Article Research Support, U.S. Gov't, P.H.S.

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J C Bornstein, H L Fields. 1979. Morphine presynaptically inhibits a ganglionic cholinergic synapse.. https://doi.org/10.1016/0304-3940(79)91532-5

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