PubMed · 2314457
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M H Stevenson, J T Hamilton. 1990-03-15. Irradiation detection.. https://doi.org/10.1038/344202b0
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The first example of a designed receptor containing a cis-1,3-disubstituted cyclobutane ring has been synthesized. This molecule binds diphosphoryl lipid A (a conserved portion of the Gram-(-) bacterial cell membrane, and the causative agent of septic shock) with an affinity comparable to previously described ter-cycloalkane based lipid A-binding compounds.
Fusarium subglutinans causes maize ear rot and contaminates grain with the mycotoxin moniliformin. Previous DNA sequence analysis divided F. subglutinans from maize into two cryptic species, designated groups 1 and 2. Here, it was determined whether the two groups differ in the agriculturally important traits of virulence on maize and moniliformin production in planta. Thirty-seven strains from U.S. maize were assigned to groups 1 and 2 by DNA sequence analysis. In field tests, all strains were highly virulent on maize inbred B73 and four maize hybrids. In planta, 82% of group 1 strains and 25% of group 2 strains produced high levels (100-1500 microg/g) of moniliformin. All group 2 strains from more northern states produced little or no moniliformin (0-5 microg/g). These data indicate that moniliformin production is highly variable in F. subglutinans from U.S. maize and that production may not be required for the fungus to cause maize ear rot.
Adenocarcinomas in rats and humans frequently contain perivascular, degranulating mast cells that release heparin. Protamine is a low-molecular weight, cationic polypeptide that binds to heparin and neutralizes its anticoagulant properties. A novel magnetic resonance imaging (MRI) contrast agent containing protamine was synthesized. TTDASQ, the derivative of TTDA (3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid), was also synthesized and the kinetic stability of [Gd(TTDASQ)]- chelate containing phosphate buffer and ZnCl2 to measure the relaxation rate (R1) at 20 MHz was studied by transmetallation with Zn(II). The water-exchange rate (k(ex)298) of [Gd(TTDASQ)]- is 6.4 x 10(6) s(-1) at 25.0 +/- 0.1 degrees C which was obtained from the reduced 17O relaxation rates (1/T(1r) and 1/T(2r)) and chemical shift (omega(r)) of H(2)17O, and it is compared with that previously reported for the other gadolinium(III) complex, [Gd(DO3ASQ)]. The binding affinity assay showed that the (TTDASQ)3-pro19 has higher activity toward heparin. On the other hand, the effect of heparin on the relaxivity of the [Gd(TTDASQ)3-pro19] conjugate shows the binding strength (K(A)) is 7669 dm3 mol(-1) at pH 7.4 and the relaxivity (r(b)1) of the [Gd(TTDASQ)3-pro19]-heparin adduct is 30.9 dm3 mmol(-1) s(-1).