Conditioned aversion after delay place conditioning with amphetamine.

P J Fudala; E T Iwamoto

doi:10.1016/0091-3057(90)90209-z

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Conditioned aversion after delay place conditioning with amphetamine.

P J Fudala·E T Iwamoto

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Abstract

Male, Sprague-Dawley rats received subcutaneous injections of either dextroamphetamine sulfate (AMP; 3.0 mg/kg) or vehicle [VEH (phosphate buffer); 1 ml/kg] immediately before (standard conditioning) or after (delay conditioning) conditioning sessions in a place-conditioning paradigm. AMP was paired for 4 conditioning sessions with one compartment of a three-compartment place-conditioning apparatus; VEH was paired for 4 conditioning sessions with another compartment. Animals were then tested for place preference or aversion by determining the proportion of time spent in each compartment during a 15-minute test session. Standard conditioning with AMP produced a place preference while delay conditioning produced a place aversion. Similar findings had earlier been reported from studies involving conditioned place-preferences and aversions with nicotine. These studies demonstrated that the time of drug administration can be as strong a determinant of place-conditioning effects as the drug itself.

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Animals Avoidance Learning Conditioning, Classical Dextroamphetamine Male Rats Rats, Inbred Strains Time Factors Journal Article Research Support, Non-U.S. Gov't

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P J Fudala, E T Iwamoto. 1990. Conditioned aversion after delay place conditioning with amphetamine.. https://doi.org/10.1016/0091-3057(90)90209-z

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