[The mechanisms of a decrease in the toxic action of cisplatin when administered jointly with preparation K-2-9 to mice with melanoma B16].

V F Chekhun; F P Pel'kis; E A Serebriakova; A S Singin; I S Sokolova; G Z Negreĭ; G I Kulik

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PubMed · 2318137

[The mechanisms of a decrease in the toxic action of cisplatin when administered jointly with preparation K-2-9 to mice with melanoma B16].

V F Chekhun·F P Pel'kis·E A Serebriakova·A S Singin·I S Sokolova·G Z Negreĭ·G I Kulik

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Abstract

The K-2-9 preparation was determined to change cis-platinum pharmacokinetics, that resulted in its pharmacodynamics alterations. The higher Pt concentrations in the blood of animals which were given the K-2-9 preparation provided selectivity of cytostatic accumulation in the tumour tissue, that was accompanied by more prolonged inhibition of the DNA synthesis. A decrease in the toxicity of cis-platinum is associated with a change in the elimination pathway and acceleration of its removal from the organism.

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Animals Cisplatin Drug Evaluation, Preclinical Drug Interactions Drug Therapy, Combination Melanoma, Experimental Mice Mice, Inbred C57BL Mice, Inbred DBA Neoplasm Transplantation Time Factors Tissue Distribution Comparative Study English Abstract Journal Article

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V F Chekhun, F P Pel'kis, E A Serebriakova, A S Singin, I S Sokolova, G Z Negreĭ, G I Kulik. 1990. [The mechanisms of a decrease in the toxic action of cisplatin when administered jointly with preparation K-2-9 to mice with melanoma B16].. https://pubmed.ncbi.nlm.nih.gov/2318137/

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