Strain-dependent differences in hippocampal glucocorticoid binding capacity and active avoidance in the mouse.

F R Patacchioli; S Puglisi-Allegra; S Maccari; P Casolini; L Angelucci; S Cabib; A Oliverio

doi:10.1016/0166-4328(90)90093-t

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Strain-dependent differences in hippocampal glucocorticoid binding capacity and active avoidance in the mouse.

F R Patacchioli·S Puglisi-Allegra·S Maccari·P Casolini·L Angelucci·S Cabib·A Oliverio

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Abstract

Maximal individual [3H]corticosterone binding capacity in the hippocampus was lower in C57BL/6 mice than in BALB/c mice, and positively correlated with active avoidance learning in the two strains. Moreover, a parallel difference in the activity of hypothalamo-pituitary adrenocortical axis (HPAA) was found, consisting in a level of plasma corticosterone in C57BL/6 higher than in BALB/c mice. These results confirm the genetically determined differences in behavior of C57BL/6 and BALB/c mice, and demonstrate their association with differences in hippocampal corticosterone binding capacity, pointing to a functional relationship between the behavioral and neuroendocrine parameters.

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Animals Avoidance Learning Corticosterone Hippocampus Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Receptors, Glucocorticoid Receptors, Steroid Species Specificity Comparative Study Journal Article

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F R Patacchioli, S Puglisi-Allegra, S Maccari, P Casolini, L Angelucci, S Cabib, A Oliverio. 1990-03-05. Strain-dependent differences in hippocampal glucocorticoid binding capacity and active avoidance in the mouse.. https://doi.org/10.1016/0166-4328(90)90093-t

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