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PubMed · 2327054

Cholinergic, anticholinergic agents and ethanol interaction.

F S Messiha
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Abstract

The effect of cholinergics and an anticholinergic agent on hepatic ethanol metabolizing enzymes was studied. Short-term administration of the cholinomimetic arecoline or the anticholinergic scopolamine induced rat liver mitochondrial aldehyde dehydrogenase (L-ALDH) isoenzyme with the apparent high and low Km, respectively. In addition, scopolamine inhibited cytoplasmic L-ALDH. This suggests differential sensitivity of the L-ALDH isoenzymes to these agents. Scopolamine and the cholinomimetic pilocarpine enhanced rat and mouse liver alcohol dehydrogenase (L-ADH) in vitro, respectively. This indicates species-dependent effect of these agents on L-ADH. The results suggest interaction of the cholinergic system with ethanol metabolizing enzymes which may contribute to the peripheral action of alcohol.

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Aldehyde DehydrogenaseAnimalsArecolineEnzyme InductionEthanolFemaleInjections, IntraperitonealLiverMaleMitochondria, LiverParasympatholyticsParasympathomimeticsPilocarpineRatsRats, Inbred StrainsScopolamineTubocurarineComparative StudyJournal Article

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F S Messiha. 1990. Cholinergic, anticholinergic agents and ethanol interaction.. https://pubmed.ncbi.nlm.nih.gov/2327054/

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