A new antileishmanial compound, phaseolinone.

R Roy; G Bhattacharya; K A Siddiqui; R Bhadra

doi:10.1016/0006-291x(90)91672-f

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A new antileishmanial compound, phaseolinone.

R Roy·G Bhattacharya·K A Siddiqui·R Bhadra

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Abstract

Inclusion of phaseolinone, a newly described mycotoxin, at 20 micrograms per ml in a solid culture medium (blood agar overlay) and at 50 micrograms per ml in a liquid culture (medium 199) inhibited the growth of L. donovani promastigotes. About 90% of the motile promastigotes lost motility after exposure to 50 micrograms per ml of phaseolinone for 6-7 h and here 3-day-old culture was more sensitive than 7-day-old culture. In an in vitro assay, DNA dependent RNA polymerase activity of 3-day-old promastigotes was considerably inhibited in the presence of this toxin. Therefore, this key enzyme was suggested to be one of the sites of action of phaseolinone.

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Animals Antiprotozoal Agents DNA-Directed RNA Polymerases Leishmania donovani Mycotoxins Naphthols Transcription, Genetic Journal Article Research Support, Non-U.S. Gov't

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R Roy, G Bhattacharya, K A Siddiqui, R Bhadra. 1990-04-16. A new antileishmanial compound, phaseolinone.. https://doi.org/10.1016/0006-291x(90)91672-f

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