PubMed Health⌕ Search

PubMed · 2342724

Consistency in nuclear medicine reporting--a pilot study using bone scans.

Abstract

In a pilot study of consistency in nuclear medicine reporting, a panel of three observers evaluated 60 bone scans carried out for detection of metastases. The bone scans had originated from 10 departments. Difficulties arose in evaluation of the quality of the images by the panel members because of the differing criteria each chose to adopt. This highlights the need to define strictly, in advance, the parameters to be included in quality assessment. All three panel members agreed on the lesions present in 54 out of 60 studies. The observers' consensus report showed material differences from the original departmental report in the number of lesions present in 10 out of 60 studies. Material differences in the interpretation of the study occurred between panel members in two cases and between the panel and the original report in four cases. The pilot study has shown an acceptable level of consistency in bone scan reporting in the departments contributing images. A national study assessing consistency of reporting would be difficult to organize but alternative, more local, schemes are suggested.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

J H McKillop, E D Williams, L K Harding. 1990. Consistency in nuclear medicine reporting--a pilot study using bone scans.. https://doi.org/10.1097/00006231-199003000-00004

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

Hematometrocolpos in an adolescent female treated for pelvic Ewing sarcoma.

Radiation therapy is often used to achieve local control of pelvic Ewing sarcoma in children. The effects of radiation on the female reproductive tract have been well documented in adults with gynecological malignancies, but the long-term consequences of pelvic radiation in pre-pubertal or adolescent girls are not as well described. We report a case of hematometrocolpos developing in an adolescent previously treated with chemotherapy and radiation therapy for pelvic Ewing sarcoma. We describe the clinical presentation, radiographic features, gross pathology, treatment strategies, outcome, as well as putative predisposing factors and preventative interventions.

Bone Neoplasms↗

Kallikrein 4 is a potential mediator of cellular interactions between cancer cells and osteoblasts in metastatic prostate cancer.

BACKGROUND: Prostate cancer (PCa) and bone cell interactions are critical in the metastatic phase. Kallikrein 4 (KLK4/hK4) is expressed in both PCa and mineralized tissues. We determined if KLK4/hK4 expression was associated with, and influenced by, the bone environment of metastatic PCa. METHODS: Immunohistochemistry, in vitro co-culture, cell migration, and attachment assays. RESULTS: hK4 was localized to tumor cells and osteoblasts in bone metastases. KLK4/hK4 increased in LNCaP and PC3 cells co-cultured with SaOs2 cells; SaOs2 KLK4/hK4 was unchanged. Co-culture did not affect cell proliferation but altered alkaline phosphatase activity/mRNA levels in SaOs2 cells. KLK4-transfected PC3 cells had increased migration towards SaOs2 conditioned medium and greater attachment to the bone-matrix proteins, collagens I and IV. CONCLUSIONS: hK4 expression and interaction with both tumor cells and osteoblasts suggests a role for hK4 in PCa bone metastasis. Whether this observation is unique to bone metastasis or reflects a role for hK4 in PCa metastasis generally is yet to be established.

Bone Neoplasms↗