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Immunoreactive interleukin-1 beta localization in the rat forebrain.

R M Lechan·R Toni·B D Clark·J G Cannon·A R Shaw·C A Dinarello·S Reichlin
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Abstract

To determine whether the cytokine, interleukin-1 beta, is present in the rat brain as has been reported in human brain, immunocytochemical studies were performed using an antiserum that recognizes recombinant, rat IL-1 beta. Immunoreaction product was present in the periventricular and medial hypothalamus, mossy fiber distribution in the hippocampus and olfactory tubercle. These studies demonstrate that IL-1 beta is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

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AnimalsFrontal LobeImmunohistochemistryInterleukin-1RabbitsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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R M Lechan, R Toni, B D Clark, J G Cannon, A R Shaw, C A Dinarello, S Reichlin. 1990-04-23. Immunoreactive interleukin-1 beta localization in the rat forebrain.. https://doi.org/10.1016/0006-8993(90)90445-h

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