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Selenium utilization in humans--a long-term, self-labeling experiment with stable isotopes.

C Veillon·K Y Patterson·L N Button·A J Sytkowski
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Abstract

A stable (nonradioactive) isotope of selenium in a chemical form common in foods (selenomethionine) or inorganic selenite was taken orally (200 micrograms/d) for 3 wk to label deep body pools. By deep body pools we mean selenium compartments that are large and/or have a slow turnover (exchange) rate. Blood plasma was removed, stored for 11 mo, and later reinfused as a labeled tracer dose with the selenium label in all of the biologically significant chemical forms. Accessible tissues such as red blood cells were highly labeled (20-25%) in the subjects receiving selenomethionine. Selenium from deep body pools is excreted primarily via the urine (80%). Reexcretion of previously absorbed selenium back into the gastrointestinal tract can be measured, avoiding a major source of error in conventional balance studies used to estimate nutrient absorption.

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Administration, OralAdultErythrocytesFecesFemaleHumansIntestinal AbsorptionIsotope LabelingIsotopesMaleMass SpectrometryMiddle AgedSeleniumSelenomethionineClinical TrialControlled Clinical TrialJournal Article

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C Veillon, K Y Patterson, L N Button, A J Sytkowski. 1990. Selenium utilization in humans--a long-term, self-labeling experiment with stable isotopes.. https://doi.org/10.1093/ajcn%2F52.1.155

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