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Antimicrobial activity of basic cholane derivatives. Part IX.

A M Bellini·E Mencini·M P Quaglio·M Guarneri·A Fini
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Abstract

Twenty new compounds derived from deoxycholic acid have been synthesized. They contain two basic functions: at C-24 (benzylamino, morpholino, diethanolamino, N,N-diethylethylenediamino, N-methylpiperazino) and at beta-C-3 (amino, methylamino, ethylamino, benzylamino). The compounds showed interesting antimicrobial activity, as expressed in terms of the low M.I.C. values (0.9-31-micrograms/ml) against five Gram(+) and four Gram(-) strains, two fungi and one yeast. The compounds inhibit the production of a fluorescent pigment in Pseudomonas aeruginosa: this result suggests that the ability to cross the bacterium cell membrane is the first step of activity. A discussion in terms of structure-activity relationship is reported.

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Anti-Bacterial AgentsAnti-Infective AgentsBacteriaChemical PhenomenaChemistryCholanesFungiMicrobial Sensitivity TestsJournal ArticleResearch Support, Non-U.S. Gov't

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A M Bellini, E Mencini, M P Quaglio, M Guarneri, A Fini. 1990. Antimicrobial activity of basic cholane derivatives. Part IX.. https://doi.org/10.1002/ardp.19903230404

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