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Quantification of the relation between electrophysiologic and morphologic changes in experimental endolymphatic hydrops.

S F Klis·J Buijs·G F Smoorenburg
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Abstract

The degree of hydrops in guinea pig ears that had undergone unilateral endolymphatic sac and duct obliteration was quantified. For 15 guinea pigs from a prior study, the correlation between the degree of hydrops and several electrophysiologic measures of the functional state of the cochlea was determined. A significant correlation between the degree of hydrops and a reduction in the low-frequency cochlear microphonic evoked by a 29-Hz tone was found. No correlation was found between the degree of hydrops and the magnitude of the summating potential evoked by 8-kHz probes. A weak correlation was found between the degree of hydrops and a reduction in the compound action potential evoked by 2-kHz probes. Possible differences in the way the endolymphatic duct obliteration exerts its effect on the different cochlear potentials are discussed.

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AnimalsDisease Models, AnimalEdemaElectrophysiologyEndolymphatic DuctEvaluation Studies as TopicEvoked Potentials, AuditoryGuinea PigsMathematicsVestibular DiseasesVestibule, LabyrinthJournal ArticleResearch Support, Non-U.S. Gov't

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S F Klis, J Buijs, G F Smoorenburg. 1990. Quantification of the relation between electrophysiologic and morphologic changes in experimental endolymphatic hydrops.. https://doi.org/10.1177/000348949009900714

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