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PubMed · 2373271

Megacolon in rats.

J S Oliveira·M A Llorach-Velludo·V N Sales-Neto
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Abstract

Four months of sigmoid colon intrinsic denervation of young male Wistar rats resulted in typical megacolon. Average 46.0% denervation of the Auerbach plexus was obtained by serosal application of benzalkonium chloride (0.2% v/v). Denervation was assessed by ganglion cell counts in a 480-nm extension of the treated segment. Increased thickness of the megacolon wall was due to muscle hypertrophy (+117.4%) and mucosal hyperplasia (+53.9%) as shown by morphometry. The potential usefulness of this experimental model is emphasized.

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AnimalsBenzalkonium CompoundsColitis, UlcerativeColon, SigmoidMaleMegacolon, ToxicMyenteric PlexusRatsRats, Inbred StrainsSympathectomy, ChemicalJournal ArticleResearch Support, Non-U.S. Gov't

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J S Oliveira, M A Llorach-Velludo, V N Sales-Neto. 1990. Megacolon in rats.. https://doi.org/10.1159/000200239

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