Impaired active avoidance responding in rats selectively bred for increased cholinergic function.

D H Overstreet; A H Rezvani; D S Janowsky

doi:10.1016/0031-9384(90)90097-n

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Impaired active avoidance responding in rats selectively bred for increased cholinergic function.

D H Overstreet·A H Rezvani·D S Janowsky

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Abstract

It was found that the Flinders Sensitive Line (FSL) of rat, selectively bred for increased cholinergic function, performed poorly in a tone-cued two-way active avoidance task in comparison with the control Flinders Restraint Line (FRL) of rat. These findings are consistent with the suggestion that the FSL rats may be a genetic animal model of depression.

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Animals Arousal Avoidance Learning Brain Cholinergic Fibers Male Motor Activity Rats Rats, Inbred Strains Receptors, Cholinergic Selection, Genetic Species Specificity Journal Article Research Support, Non-U.S. Gov't

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D H Overstreet, A H Rezvani, D S Janowsky. 1990. Impaired active avoidance responding in rats selectively bred for increased cholinergic function.. https://doi.org/10.1016/0031-9384(90)90097-n

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