Fibroblast growth factor in chick osteogenesis.

S R Frenkel; D A Grande; M Collins; I J Singh

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PubMed · 2397257

Fibroblast growth factor in chick osteogenesis.

S R Frenkel·D A Grande·M Collins·I J Singh

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Abstract

In vivo effects of FGF on osteogenesis in the chick embryo were evaluated. Day-11 embryos were injected with FGF followed by radiotracers. 3H-thymidine labelling of osteogenic cells was significantly higher following FGF administration; 3H-proline labelling over bone matrix was greater in the controls. Cartilage cells and matrix were sparsely labelled indicating a low level of metabolic activity. These data provide the first in vivo evidence that FGF stimulates osteogenic cell proliferation, while inhibiting production of bone matrix collagen. A role for FGF in embryonic osteogenesis and in fracture repair is suggested.

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Animals Autoradiography Chick Embryo Fibroblast Growth Factors Osteogenesis Journal Article

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S R Frenkel, D A Grande, M Collins, I J Singh. 1990. Fibroblast growth factor in chick osteogenesis.. https://pubmed.ncbi.nlm.nih.gov/2397257/

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