How does cisplatin alter DNA structure? A molecular mechanics study on double-stranded oligonucleotides.

J Kozelka; J C Chottard

doi:10.1016/0301-4622(90)80006-s

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How does cisplatin alter DNA structure? A molecular mechanics study on double-stranded oligonucleotides.

J Kozelka·J C Chottard

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Abstract

Molecular models for two double-stranded decanucleotides, d(GCCG*G*ATCGC)-d(GCGATCCGGC) (1) and d(GCTG*G*ATCGC)-d(GCGATCCAGC) (2), with the G* guanines cross-linked by a cis-Pt(NH3)2 moiety, were calculated using molecular mechanics. Nine models for 1 and eight models for 2 are reported; in all of them, the double helix is kinked by approx. 60 degrees towards the major groove and slightly unwound. The model building has been guided by comparison with the NMR data available for duplex 1. The influence of the base at the 5'-side of the coordinated G*G* dinucleotide is discussed.

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Base Sequence Carbohydrates Cisplatin DNA Hydrogen Bonding Models, Molecular Molecular Conformation Molecular Sequence Data Oligonucleotide Probes Phosphates Platinum Journal Article Research Support, Non-U.S. Gov't

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J Kozelka, J C Chottard. 1990. How does cisplatin alter DNA structure? A molecular mechanics study on double-stranded oligonucleotides.. https://doi.org/10.1016/0301-4622(90)80006-s

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