Peptide competition for antigen presentation.

L Adorini; Z A Nagy

doi:10.1016/0167-5699(90)90006-u

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Peptide competition for antigen presentation.

L Adorini·Z A Nagy

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Abstract

Since each major histocompatibility complex (MHC) molecule can bind many different peptides, it might be predicted that competition for the same MHC-binding site takes place between peptides with unrelated sequences. As Luciano Adorini and Zoltan Nagy report here, this does indeed occur, both in vitro and in vivo. In-vivo competition between peptides for antigen presentation to T lymphocytes is an important influence on the immunodominance of T-cell determinants. In addition, it is possible to modulate T-cell activation by interfering with the binding of antigenic peptides to MHC class II molecules. This could represent a suitable approach to a rational treatment of autoimmune diseases and, possibly, of allograft rejection.

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Animals Antigen-Presenting Cells Binding Sites Binding, Competitive Histocompatibility Antigens Peptides Journal Article Review

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L Adorini, Z A Nagy. 1990. Peptide competition for antigen presentation.. https://doi.org/10.1016/0167-5699(90)90006-u

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