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PubMed · 2409019

Donor sensitivity to basophil activation by eosinophil granule major basic protein.

L M Zheutlin·S J Ackerman·G J Gleich·L L Thomas
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Abstract

Leukocytes of 22 individuals were incubated with a suboptimal concentration of eosinophil granule major basic protein and the amount of histamine release was determined. Cells from 20 of the 22 donors had a histamine release of greater than or equal to 15%. The use of selected donors on repeated occasions revealed significant variability in individual donor responsiveness. The findings support a role for major basic protein activation of human basophils in allergic reactions.

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BasophilsBlood ProteinsCells, CulturedEosinophil Granule ProteinsEosinophilsHistamine ReleaseHumansRibonucleasesJournal Article

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L M Zheutlin, S J Ackerman, G J Gleich, L L Thomas. 1985. Donor sensitivity to basophil activation by eosinophil granule major basic protein.. https://doi.org/10.1159/000233791

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