Protons decrease the single channel conductance of the sarcoplasmic reticulum K+ channel in neutral and negatively charged bilayers.

J Bell

doi:10.1016/s0006-3495(85)83790-5

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Protons decrease the single channel conductance of the sarcoplasmic reticulum K+ channel in neutral and negatively charged bilayers.

J Bell

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Abstract

The conductance of rabbit sarcoplasmic reticulum K+ channels incorporated into artificial bilayers of varying lipid composition was measured at different K+ and proton concentrations. Protons competitively inhibit the K+ conductance with a Ki of 0.5 microM. In negatively charged membranes, the conductance is well described by Gouy-Chapman-Stern theory modified to include the inhibitory effect of protons of the conductance and assuming that the channel mouth is isolated by 5-10 A from bilayer surface.

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Animals Electric Conductivity Hydrogen-Ion Concentration Ion Channels Kinetics Lipid Bilayers Potassium Rabbits Sarcoplasmic Reticulum Thermodynamics Journal Article Research Support, Non-U.S. Gov't

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J Bell. 1985. Protons decrease the single channel conductance of the sarcoplasmic reticulum K+ channel in neutral and negatively charged bilayers.. https://doi.org/10.1016/s0006-3495(85)83790-5

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