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PubMed · 2416045

[Interleukin 1].

A Fontana·S Bodmer·K Frei
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Abstract

Interleukin-1 (IL-1) is secreted by macrophages, macrophage-like cells (e.g. Langerhans cells) and by astrocytes, keratinocytes, fibroblasts or natural killer cells. IL-1 is directly involved in the activation of helper T lymphocytes. However, it has been shown that IL-1 also induces release of collagenase and prostaglandins by fibroblasts. Furthermore, injections of IL-1 into animals are followed by fever, leukocytosis, increased serum concentrations of fibrinogen, serum amyloid A and haptoglobin, and decreased levels of iron and zinc. IL-1 has been extracted from experimental granuloma and from tissues of animals with endotoxinemia. Synovial fluids from patients with osteoarthritis contain significant amounts of IL-1. All in all, IL-1 may be ultimately involved in the development of fever and fibrosis, in the destruction of joints and the activation of T lymphocytes during inflammatory processes.

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AnimalsChemical PhenomenaChemistryEpitopesFeverHumansInflammationInterleukin-1MacrophagesMiceOsteoarthritisProstaglandins EProtein BiosynthesisPulmonary FibrosisPyrogensRatsSleepSynovial FluidT-Lymphocytes, Helper-InducerEnglish AbstractJournal ArticleReview

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A Fontana, S Bodmer, K Frei. 1985-10-12. [Interleukin 1].. https://pubmed.ncbi.nlm.nih.gov/2416045/

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