Rotavirus antigens.

M K Estes; D Y Graham

doi:10.1007/978-1-4684-7974-4_13

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Rotavirus antigens.

M K Estes·D Y Graham

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Abstract

The rotaviruses are important medical and veterinary pathogens that cause acute diarrheal disease in children and in the young of most mammalian and avian species. The successful development of a rotavirus vaccine should significantly reduce worldwide infant morbidity and mortality and economic losses and increase food-production. Recent successes in the cultivation and characterization of rotavirus strains from humans and animals have led to a better understanding of the major antigens of these viruses and the genes encoding these antigens. The products of three independent genes (1) the neutralization antigen (the outer capsid glycoprotein); (2) the subgroup antigen (the major inner capsid protein); and (3) the hemagglutinin (the outer capsid protease-sensitive protein) are the major viral antigens. The properties and structure of these antigens are discussed. Further knowledge should facilitate the synthesis and development of novel antigen or subunit vaccines.

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Animals Antigens, Viral Epitopes Genes, Viral Hemagglutinins, Viral Humans Microscopy, Electron Molecular Weight Neutralization Tests Protein Conformation Rotavirus Viral Proteins Viral Vaccines Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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M K Estes, D Y Graham. 1985. Rotavirus antigens.. https://doi.org/10.1007/978-1-4684-7974-4_13

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