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Clustered homeo boxes are differentially expressed during murine development.

A M Colberg-Poley·S D Voss·K Chowdhury·C L Stewart·E F Wagner·P Gruss
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Abstract

A murine homeo box (m6-12) known to be expressed during differentiation of embryonal carcinoma cells lies within a cluster of homeo boxes located in 30 kilobase pairs of genomic DNA. We have established the organization of the boxes within this complex, as well as the nucleotide sequence of a second box, m5-4. Similar to the m6-12 box, expression of novel m5-4 transcripts is induced upon differentiation of embryonal carcinoma cells. Transcripts of genes containing m6-12 were found in embryonic tissue during almost all stages of prenatal development studied, whereas expression of m5-4 was detected only in 12 day embryonic tissue. Finally, we have described the differential expression of these homeo-box-containing regions in various adult tissues.

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Amino Acid SequenceAnimalsCell LineChromosome MappingCloning, MolecularEmbryo, MammalianEmbryonal Carcinoma Stem CellsGene Expression RegulationGenesMiceMice, Inbred ICRMorphogenesisNeoplastic Stem CellsNucleic Acid HybridizationPoly AProtein BiosynthesisRNARNA, MessengerSequence Homology, Nucleic AcidTeratomaTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov't

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A M Colberg-Poley, S D Voss, K Chowdhury, C L Stewart, E F Wagner, P Gruss. 1985. Clustered homeo boxes are differentially expressed during murine development.. https://doi.org/10.1016/0092-8674(85)90010-8

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