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PubMed · 2423824

Immunomodulation by some oligopeptides.

I Paegelow·H Werner
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Abstract

The influence of bradykinin, some of its analogues, substance P and different partial sequences on lymphoid cells was studied under in vitro conditions. The oligopeptides bradykinin and substance P were found to be able to induce the secretion of charge-changing and chemokinetic lymphokines in very low concentrations. In each case, bell-shaped dose-response curves were registered in a concentration range from 10(-12) to 10(-6) M. An analysis of the lymphokine patterns suggests that T cells are the producer cells of charge-changing lymphokines. Comparing the structure-activity relationships of the peptides, the amino acid sequence Arg-Pro at the N-terminal region of bradykinin and substance P or Pro-Arg at the C-terminal part of tuftsin and rigin appear to be responsible for the lymphokine secretion.

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Adjuvants, ImmunologicAnimalsBradykininChemotaxis, LeukocyteConcanavalin AElectrophoresisIn Vitro TechniquesLymphocytesLymphokinesMiceMice, Inbred CBAOligopeptidesRatsRats, Inbred StrainsSubstance PJournal Article

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I Paegelow, H Werner. 1986. Immunomodulation by some oligopeptides.. https://pubmed.ncbi.nlm.nih.gov/2423824/

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