Collagen-derived peptides release mast cell histamine.

J Wize; E Wojtecka-Lukasik; S Maśliński

doi:10.1007/bf01988037

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Collagen-derived peptides release mast cell histamine.

J Wize·E Wojtecka-Lukasik·S Maśliński

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Abstract

The effect of collagen degradation products by bacterial (BCDP) and synovial fluid collagenase (SCDP) on histamine release from peritoneal mast cells of rat was estimated. Some BCDP as well as SCDP released 60-80% of mast cell histamine. In BCDP fraction the most active were BCDP II (m.wt. 13 kD) and BCDP III (m.wt. 6 kD). The last contained the highest percentage of hydroxyproline. As compared with bradykinin, BCDP III was about 50 fold more active as histamine releaser.

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Animals Bacteria Collagen Connective Tissue Diseases Histamine Release In Vitro Techniques Male Mast Cells Microbial Collagenase Peptides Rats Rats, Inbred Strains Synovial Fluid Journal Article Research Support, Non-U.S. Gov't

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J Wize, E Wojtecka-Lukasik, S Maśliński. 1986. Collagen-derived peptides release mast cell histamine.. https://doi.org/10.1007/bf01988037

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