Acetylation phenotype and skin complexion.

F H Rampen; H L van der Meeren; L M Stolk

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PubMed · 2430405

Acetylation phenotype and skin complexion.

F H Rampen·H L van der Meeren·L M Stolk

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Abstract

The relationship of acetylation phenotype to skin complexion was studied in 155 healthy Caucasians. Individuals received 500 mg sulphadimidine at 11.00 p.m.; urine was collected eight hours later. The percentage of acetylated sulphadimidine in urine was measured with high performance liquid chromatography. There was a slight but insignificant preponderance of slow acetylators in the dark skin types. It is concluded that slow acetylation phenotype is not correlated with light skin complexion. Therefore, it is unlikely that acetylation of xenobiotic carcinogens plays a dominant role in melanoma risk.

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Acetyltransferases Adult Female Humans Male Melanoma Phenotype Risk Skin Neoplasms Skin Pigmentation Sulfamethazine Comparative Study Journal Article

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F H Rampen, H L van der Meeren, L M Stolk. 1986. Acetylation phenotype and skin complexion.. https://pubmed.ncbi.nlm.nih.gov/2430405/

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