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Thymus involution induced by 5-azacytidine.

A Csordas·K Schauenstein
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Abstract

Hypomethylation of DNA, which can be achieved by incorporation of 5-azacytidine, has been correlated with derepression of genes. In order to examine the in vivo effects of 5-azacytidine on organ development and differentiation, young rats were treated with the drug. There was an almost complete reduction of thymus and a marked reduction of spleen weight, while other organs, including testes were only marginally affected. Control experiments with cytosine-arabinoside suggest that treatment with an inhibitor of DNA replication per se is not responsible for the very rapid thymus involution triggered by 5-azacytidine in rats. In spite of the drastic reduction of thymus and spleen weight, lymphocytes of these organs were not impaired in their response to the T cell mitogen Concanavalin A.

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AnimalsAzacitidineCytarabineDNA ReplicationDose-Response Relationship, DrugKineticsMaleOrgan SizeRatsRats, Inbred StrainsThymus GlandJournal ArticleResearch Support, Non-U.S. Gov't

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A Csordas, K Schauenstein. 1986. Thymus involution induced by 5-azacytidine.. https://doi.org/10.1007/bf01114754

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