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PubMed · 2433769

Immunological self, nonself discrimination.

J G Guillet·M Z Lai·T J Briner·S Buus·A Sette·H M Grey·J A Smith·M L Gefter
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Abstract

The ability of immunodominant peptides derived from several antigen systems to compete with each other for T cell activation was studied. Only peptides restricted by a given transplantation antigen are mutually competitive. There is a correlation between haplotype restriction, ability to bind to the appropriate transplantation antigen, and ability to inhibit activation of other T cells restricted by the same transplantation antigen. An exception was noted in that a peptide derived from an antigen, bacteriophage lambda cI repressor, binds to the I-Ed molecule in a specific way, yet is not I-Ed-restricted. Comparison of the sequence of the repressor peptide with that of other peptides able to bind to (and be restricted by) I-Ed and a polymorphic region of the I-Ed molecule itself revealed a significant degree of homology. Thus, peptides restricted by a given class II molecule appear to be homologous to a portion of the class II molecule itself. The repressor-derived peptide is identical at several polymorphic residues at this site, and this may account for the failure of I-Ed to act as a restriction element. Comparison of antigenic peptide sequences with transplantation antigen sequences suggests a model that provides a basis for explaining self, nonself discrimination as well as alloreactivity.

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AnimalsAntigensAutoantigensDNA-Binding ProteinsEpitopesHistocompatibility Antigens Class IIHybridomasIsoantigensLymphocyte ActivationMiceMicrococcal NucleaseOvalbuminProtein BindingReceptors, ImmunologicRepressor ProteinsT-LymphocytesT-Lymphocytes, Helper-InducerViral ProteinsViral Regulatory and Accessory ProteinsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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J G Guillet, M Z Lai, T J Briner, S Buus, A Sette, H M Grey, J A Smith, M L Gefter. 1987-02-20. Immunological self, nonself discrimination.. https://doi.org/10.1126/science.2433769

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