Microvascular density changes during wound-healing.

H Hashimoto; R L Prewitt

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PubMed · 2435668

Microvascular density changes during wound-healing.

H Hashimoto·R L Prewitt

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Abstract

Vessel densities of arterioles, capillaries, venules and A-V anastomoses were determined during wound-healing following implantation of the rabbit ear chamber. Arterioles were defined on the basis of the direction of blood flow and the presence of a muscular coat. Capillaries were endothelial cell tubes with single-file flow of erythrocytes. Venules were thin-walled vessels collecting blood flow from capillaries and carrying blood flow from the tissue. A-V anastomoses were thick-walled, unbranched vessels carrying blood flow from an arteriole to a venule. Arteriolar density was relatively higher in the earlier stages but venular density was higher in the later stages of wound-healing. The fractional density was highest 2 weeks after implantation for arterioles (17.9%), at 4 weeks for capillaries (39.3%), and at 10 weeks for venules (56.9%). No significant change was observed in the density of A-V anastomoses. This study suggests that the rates of growth and decay are different among each vessel category during wound-healing.

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Animals Ear, External Male Microcirculation Neovascularization, Pathologic Rabbits Wound Healing Journal Article Research Support, U.S. Gov't, P.H.S.

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H Hashimoto, R L Prewitt. 1987. Microvascular density changes during wound-healing.. https://pubmed.ncbi.nlm.nih.gov/2435668/

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