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PubMed · 2439072

Modulation of monocyte complement synthesis by interferons.

A O Hamilton·L Jones·L Morrison·K Whaley
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Abstract

Recombinant Escherichia coli-derived gamma-interferon has been shown to stimulate synthesis of the second component of complement (C2), factor B and C1 inhibitor, but to inhibit synthesis of the third component (C3). alpha- and beta-interferons stimulate synthesis of factor B and C3 inhibitor, inhibit C5 synthesis but do not alter synthesis of C2. alpha- and beta-interferons act synergistically with gamma-interferon to enhance both factor B and C1-inhibitor synthesis.

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Cells, CulturedChemical PrecipitationComplement Factor BComplement System ProteinsDose-Response Relationship, DrugHumansInterferon Type IInterferon-gammaInterferonsKineticsMonocytesJournal ArticleResearch Support, Non-U.S. Gov't

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A O Hamilton, L Jones, L Morrison, K Whaley. 1987-03-15. Modulation of monocyte complement synthesis by interferons.. https://doi.org/10.1042/bj2420809

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