Increase of enkephalin and decrease of substance P immunoreactivity in the dorsal and ventral striatum of the rat after midbrain 6-hydroxydopamine lesions.

P Voorn; G Roest; H J Groenewegen

doi:10.1016/0006-8993(87)91149-8

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Increase of enkephalin and decrease of substance P immunoreactivity in the dorsal and ventral striatum of the rat after midbrain 6-hydroxydopamine lesions.

P Voorn·G Roest·H J Groenewegen

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Abstract

Unilateral 6-hydroxydopamine lesions of the mesostriatal dopaminergic system in the rat resulted in a decrease of substance P-immunoreactivity in the ventral striatum, and in a heterogeneously distributed increase of enkephalin-immunoreactivity in the dorsal and ventral striatum and the globus pallidus. The respective decrease and increase are caused by a lower or higher staining intensity of the peptidergic fibers, whereas no changes were found in the cell bodies.

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Afferent Pathways Animals Corpus Striatum Dopamine Efferent Pathways Enkephalins Histocytochemistry Hydroxydopamines Nucleus Accumbens Oxidopamine Rats Substance P Journal Article

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P Voorn, G Roest, H J Groenewegen. 1987-06-02. Increase of enkephalin and decrease of substance P immunoreactivity in the dorsal and ventral striatum of the rat after midbrain 6-hydroxydopamine lesions.. https://doi.org/10.1016/0006-8993(87)91149-8

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