Transmembrane ionic transport systems and hypertension.

M Lazdunski

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PubMed · 2449076

Transmembrane ionic transport systems and hypertension.

M Lazdunski

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Abstract

Various systems contribute to the regulation of intracellular calcium. The most important are: (1) the voltage-dependent calcium channel; (2) sodium/calcium exchange, resulting in a correlation between intracellular sodium and calcium; (3) plasma membrane calcium ATPase; and (4) the inositol triphosphate-regulated channel, releasing calcium from the endoplasmic and sarcoplasmic reticulum stores. The essential properties of these different systems, their pharmacologic features, and their regulation by various agonists (beta- and alpha-adrenergic angiotensin-type peptides, etc.) must be considered both for an understanding of the pathophysiology of hypertension and for its treatment.

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Animals Biological Transport Calcium Cell Membrane Humans Hypertension Ion Channels Muscle, Smooth Myocardium Sodium Journal Article Review

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M Lazdunski. 1988-01-29. Transmembrane ionic transport systems and hypertension.. https://pubmed.ncbi.nlm.nih.gov/2449076/

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