Kainic acid lesions decrease striatal dopamine receptors and 1,4-dihydropyridine sites.

A Skattebøl; R E Hruska; M Hawthorn; D J Triggle

doi:10.1016/0304-3940(88)90485-5

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Kainic acid lesions decrease striatal dopamine receptors and 1,4-dihydropyridine sites.

A Skattebøl·R E Hruska·M Hawthorn·D J Triggle

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Abstract

The effects of intrastriatal injection of kainic acid (2 microliters, 1 mg/ml) in the rat were determined. Four weeks after the lesioning, striatal dopamine receptors and 1,4-dihydropyridine sites were measured by radioligand binding with [3H]spiperone and [3H]nimodipine, respectively. Dopamine receptor and 1,4-dihydropyridine binding densities were decreased by 58% and 43% respectively, with no change in binding affinity for either ligand. 1,4-Dihydropyridine-sensitive Ca2+ channels may be located primarily on postsynaptic elements.

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Animals Binding Sites Calcium Channels Choline O-Acetyltransferase Corpus Striatum Dihydropyridines Ion Channels Kainic Acid Male Nimodipine Rats Receptors, Dopamine Receptors, Nicotinic Spiperone Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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A Skattebøl, R E Hruska, M Hawthorn, D J Triggle. 1988-06-17. Kainic acid lesions decrease striatal dopamine receptors and 1,4-dihydropyridine sites.. https://doi.org/10.1016/0304-3940(88)90485-5

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