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PubMed · 2458201

The Abbott IMx automated benchtop immunochemistry analyzer system.

M Fiore·J Mitchell·T Doan·R Nelson·G Winter·C Grandone·K Zeng·R Haraden·J Smith·K Harris
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Abstract

We describe a new clinical laboratory instrument, the IMx, used to automate immunoassay testing in the clinical laboratory. The IMx incorporates a novel technology called Microparticle capture Enzyme ImmunoAssay (MEIA) for assays of high-molecular-mass analytes, and fluorescence polarization immunoassay (FPIA) for hapten assays. A front-surface fluorometer is used to quantify the enzymatic generation of fluorescent product at a rate proportional to the concentration of the analyte in an MEIA, and a fluorescence polarization optical system is used to quantify results in an FPIA. The microprocessor-based instrument uses a robotic arm with two degrees of freedom and a rotating carousel to process the samples for assay. One assay can be done on each of 24 patients' specimens in 30 to 40 min with "walk-away" automation. Calibration curves are stable for at least two weeks. Instrument control involves software-labeled "command keys," a numeric keypad, and an interactive display. Results are output to a thermal printer or computer interface.

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AutoanalysisChorionic GonadotropinFluorescence PolarizationFluorometryHot TemperatureHumansHymecromoneImmunoassayImmunoenzyme TechniquesOptics and Photonicsalpha-FetoproteinsJournal Article

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M Fiore, J Mitchell, T Doan, R Nelson, G Winter, C Grandone, K Zeng, R Haraden, J Smith, K Harris. 1988. The Abbott IMx automated benchtop immunochemistry analyzer system.. https://pubmed.ncbi.nlm.nih.gov/2458201/

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