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Liver cell rosettes: structural differences in cholestasis and hepatitis.

N Nagore·S Howe·L Boxer·P J Scheuer
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Abstract

Cholestatic and hepatitic liver cell rosettes, gland-like formations found respectively in chronic cholestasis and in chronic active hepatitis, represent structural modifications of liver cell plates in response to injury. Differences in cytokeratin expression, ultrastructure and three-dimensional (3-D) configuration have been investigated. Cholestatic rosettes are considered to be a form of biliary metaplasia of hepatocytes, linking with newly-formed bile ductules in adjacent septa and probably providing some protection from injury caused by abnormal bile constituents. Hepatitis rosettes, by contrast, are a form of liver cell regeneration developing in isolated surviving hepatocytes or small groups of hepatocytes within areas of collapse.

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Bile CanaliculiBiopsyCholestasisHepatitis CHepatitis, ChronicHumansImmunoenzyme TechniquesKeratinsLiverLiver Cirrhosis, BiliaryLiver RegenerationMicroscopy, ElectronJournal ArticleResearch Support, Non-U.S. Gov't

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N Nagore, S Howe, L Boxer, P J Scheuer. 1989. Liver cell rosettes: structural differences in cholestasis and hepatitis.. https://doi.org/10.1111/j.1600-0676.1989.tb00377.x

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