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Salmonella, complement and mouse macrophages.

P H Mäkelä·M Hovi·H Saxén·M Valtonen·V Valtonen
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Abstract

The structure of the polysaccharide chains that constitute the O antigen on the surface of Salmonella bacteria determines the rate of complement activation and C3b deposition on the bacteria. A fast-activating O antigen causes rapid C3-dependent opsonization of the bacteria injected intraperitoneally; as a consequence, the bacteria are taken up and killed by the resident peritoneal macrophages, and their virulence is low. A slow-activating O antigen protects the bacteria from opsonization in the peritoneal cavity, and is associated with higher virulence. However, if injected intravenously bacteria with either O-antigenic type are equally virulent; in the high complement concentration of the blood they become opsonized and taken up by macrophages in the liver and spleen, which are unable to kill them but instead provide a protected site for multiplication.

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AnimalsAntigens, BacterialComplement ActivationComplement System ProteinsMacrophagesMiceO AntigensSalmonella Infections, AnimalSalmonella typhimuriumJournal Article

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P H Mäkelä, M Hovi, H Saxén, M Valtonen, V Valtonen. 1988. Salmonella, complement and mouse macrophages.. https://doi.org/10.1016/0165-2478(88)90145-9

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