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FK-506--how much potential?

A W Thomson
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Abstract

FK-506 is a recently discovered immunosuppressive agent that, although structurally quite distinct from cyclosporin A (CsA), shares many of its properties. These include interference with production of interleukin 2 (IL-2) and other lymphokines, lack of myelotoxicity and the induction of transplantation tolerance following administration of short courses to allografted rats. Compared with CsA, however, FK-506 is much more potent and the two agents can act synergistically both in vivo and in vitro. However, severe side effects of FK-506 have been reported in dogs and baboons, although not in rats. On the basis of recently published findings. Angus Thomson reviews the immunological properties of FK-506 and assesses its potential in the light of the impact already made by CsA in both the laboratory and clinic.

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AnimalsAutoimmune DiseasesCyclosporinsDrug Evaluation, PreclinicalDrug SynergismGraft SurvivalImmunosuppressive AgentsMiceMolecular ConformationPrimatesPyridinesRatsStructure-Activity RelationshipTacrolimusComparative StudyJournal ArticleReview

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A W Thomson. 1989. FK-506--how much potential?. https://doi.org/10.1016/0167-5699(89)90057-1

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