Do ribosomes regulate mitochondrial RNA synthesis?

H T Jacobs

doi:10.1002/bies.950110108

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Do ribosomes regulate mitochondrial RNA synthesis?

H T Jacobs

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Abstract

The levels of different classes of mitochondrially encoded transcripts are developmentally regulated in sea urchin embryos, as a result of selection between mutually exclusive synthetic pathways. I propose a simple model to explain these observations, based on a dual role for mitochondrial ribosomes and translation factors in RNA synthesis as well as in translation. This effect may be exerted either at the transcriptional or post-transcriptional level (or both), and is potentially generalizable to mammalian mtDNA and to other systems.

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Animals Gene Expression Regulation Protein Biosynthesis RNA RNA, Mitochondrial Ribosomes Sea Urchins Journal Article Research Support, Non-U.S. Gov't Review

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H T Jacobs. 1989. Do ribosomes regulate mitochondrial RNA synthesis?. https://doi.org/10.1002/bies.950110108

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