Three dimensional structure of a functional internal image.

W V Williams; H R Guy; D B Weiner; M I Greene

doi:10.1089/vim.1989.2.239

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Three dimensional structure of a functional internal image.

W V Williams·H R Guy·D B Weiner·M I Greene

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Abstract

An anti-idiotypic antibody has been characterized that forms a functional internal image of the cell-attachment site of reovirus type 3. This antibody shares sequence similarity with the reovirus type 3 cell attachment protein. Studies utilizing synthetic peptides have shown that the region of sequence similarity corresponds to the cell-attachment site of the virus and the antibody. Studies are described demonstrating that these peptides possess biological activity similar to that of the virus and the antibody. Three-dimensional models of the cell-attachment site of the virus are presented and compared to a similar model for the antibody. These studies indicate that anti-idiotypic antibodies can be utilized to understand the three-dimensional basis of ligand - receptor interactions, and can lead to the development of novel biologically active substances.

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Amino Acid Sequence Animals Antibodies, Anti-Idiotypic Binding Sites, Antibody Epitopes Hemagglutinins, Viral Immunization Lymphocyte Activation Mammalian orthoreovirus 3 Mice Models, Molecular Molecular Sequence Data Peptides Protein Conformation Reoviridae Journal Article

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W V Williams, H R Guy, D B Weiner, M I Greene. 1989. Three dimensional structure of a functional internal image.. https://doi.org/10.1089/vim.1989.2.239

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