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Interferon effects on osteoinduction.

J T Triffitt·H C Bauer·O Brosjo·C J Joyner·S Forster
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Abstract

Xenografts of human osteosarcoma growing in athymic mice are inhibited in growth rate by human interferon-alpha (IFN-alpha) treatment. In addition, differentiation of trabecular bone occurs external to the osteosarcomatous tissue and this is entirely dependent on IFN treatment. We have used species-specific anticollagens and antivimentin antibodies to determine the species origins of this trabecular bone. By using immunohistochemical procedures, it was found that this bone is host-derived. These results suggest that IFN provoked the production of a bone-inducing agent by the human osteosarcomas.

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AnimalsCollagenFemaleImmunohistochemistryInterferonsMiceMice, Inbred BALB CMice, NudeOsteogenesisOsteosarcomaSpecies SpecificityTumor Cells, CulturedJournal Article

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J T Triffitt, H C Bauer, O Brosjo, C J Joyner, S Forster. 1989. Interferon effects on osteoinduction.. https://doi.org/10.3109/03008208909002414

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