Amyloid enhancing factor (AEF) in the aging mouse.

T Yokota; T Ishihara; H Kawano; M Takahashi; Y Fujinaga; F Uchino

doi:10.1007/bf00781708

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Amyloid enhancing factor (AEF) in the aging mouse.

T Yokota·T Ishihara·H Kawano·M Takahashi·Y Fujinaga·F Uchino

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Abstract

Amyloid enhancing factor (AEF) activity was tested in spleen homogenates from 52, 28, and 9-week-old untreated mice. Strong AEF activity was present in the supernatant of spleen homogenate from the 52-week-old mice. Only weak activity was observed in the supernatant from the 28-week-old mice, and none was seen in that from the 9-week-old mice. Crude spleen homogenates from the 52-week-old mice were subjected to Sephacryl S-300 gel filtration. AEF activity existed in the first gel filtration peak. These findings suggest that AEF increases in the spleens of aged mice and that AEF may be a substance of high molecular weight.

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Aging Animals Chromatography, Gel Glycoproteins Immunohistochemistry Mice Mice, Inbred Strains Spleen Comparative Study Journal Article Research Support, Non-U.S. Gov't

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T Yokota, T Ishihara, H Kawano, M Takahashi, Y Fujinaga, F Uchino. 1989. Amyloid enhancing factor (AEF) in the aging mouse.. https://doi.org/10.1007/bf00781708

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