The oncogene jun and nuclear signalling.

P K Vogt; T J Bos

doi:10.1016/0968-0004(89)90268-5

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The oncogene jun and nuclear signalling.

P K Vogt·T J Bos

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Abstract

Jun is a transcription factor that can also induce oncogenic transformation. Its DNA-binding domain is conserved from yeast to man and shows homology to several other transcriptional regulators. Jun dimerizes with the fos protein through an alpha-helical domain termed the leucine zipper, and the jun-fos heterodimers bind to DNA and regulate transcription of numerous specific unlinked genes.

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Animals DNA-Binding Proteins Humans Oncogene Protein p65(gag-jun)Retroviridae Proteins Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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P K Vogt, T J Bos. 1989. The oncogene jun and nuclear signalling.. https://doi.org/10.1016/0968-0004(89)90268-5

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