Polymorphonuclear leukocyte function in HIV-1-infected chimpanzees.

L J Lafrado; D A Quintana; M A Javadian; J C Kelliher

doi:10.1016/0165-2427(89)90125-6

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Polymorphonuclear leukocyte function in HIV-1-infected chimpanzees.

L J Lafrado·D A Quintana·M A Javadian·J C Kelliher

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Abstract

The chemiluminescent characteristics of enriched populations of neutrophils from control and HIV-infected chimpanzees were assessed. Neutrophils from HIV-infected chimpanzees were suppressed in their ability to generate a normal response to particulate and soluble stimuli when compared to normal and hepatitis non-A, non B-infected controls. Particulate (latex beads) stimulation of neutrophils resulted in an aberrant response when contrasted with controls. Normal control responses were characteristically biphasic while the response from hepatitis NANB HIV-infected chimpanzees was not biphasic. Neutrophils challenged with a soluble (phorbol ester) stimulant also demonstrated a suppressed response. These data suggest that HIV infection has an additive suppressive effect on neutrophil function in chimpanzees previously infected with hepatitis NANB. The suppression of chimpanzee neutrophil function following HIV infection is similar to that seen in other non-primate viral and retroviral infections.

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Acquired Immunodeficiency Syndrome Animals HIV-1 Hepatitis C Luminescent Measurements Neutrophils Pan troglodytes Tetradecanoylphorbol Acetate Comparative Study Journal Article Research Support, U.S. Gov't, P.H.S.

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L J Lafrado, D A Quintana, M A Javadian, J C Kelliher. 1989. Polymorphonuclear leukocyte function in HIV-1-infected chimpanzees.. https://doi.org/10.1016/0165-2427(89)90125-6

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