Thyroxine-binding globulin and thyroxine-binding prealbumin in hypothyroid and hyperthyroid developing rats.

L Savu; R Vranckx; M Maya; D Gripois; M F Blouquit; E A Nunez

doi:10.1016/0304-4165(89)90100-1

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Thyroxine-binding globulin and thyroxine-binding prealbumin in hypothyroid and hyperthyroid developing rats.

L Savu·R Vranckx·M Maya·D Gripois·M F Blouquit·E A Nunez

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Abstract

We present evidence based on equilibrium and non-equilibrium binding studies, as well as on immunological techniques, that of the two rat specific thyroid-hormone-binding proteins, i.e., thyroxine-binding globulin (TBG) and thyroxine-binding prealbumin (TBPA), TBG but not TBPA is regulated by the thyroid hormones (TH). Hypothyroidism, induced from the day of birth by daily treatment with propylthiouracil (PTU-rats), leads to dramatic and sustained increases of the TH-binding abilities of the sera measured at equilibrium, whereas hyperthyroidism, induced by treatment with thyroxine (T4-rats), leads to the decrease of these abilities. Polyacrylamide gel electrophoresis and isoelectrofocalisation of radioiodinated T4-labelled sera, together with immunoassay of TBPA, demonstrate that both effects are due to TBG, the levels of which rise in PTU-rats and decline in T4-rats, while TBPA levels do not respond to either depletion or excess of the thyroid hormones. TBG rather than TBPA appears as the key thyroid-hormone-binding protein of the rat, inasmuch as it alone expresses a regulatory function of the thyroid hormones at protein synthesis level.

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Aging Animals Hyperthyroidism Hypothyroidism Kinetics Propylthiouracil Rats Rats, Inbred Strains Thyroxine Thyroxine-Binding Proteins Triiodothyronine Journal Article Research Support, Non-U.S. Gov't

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L Savu, R Vranckx, M Maya, D Gripois, M F Blouquit, E A Nunez. 1989-09-15. Thyroxine-binding globulin and thyroxine-binding prealbumin in hypothyroid and hyperthyroid developing rats.. https://doi.org/10.1016/0304-4165(89)90100-1

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