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PubMed · 251348

Methicillin-resistant Staphylococcus epidermidis.

W T Siebert·N Moreland·T W Williams
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Abstract

Staphylococcus epidermidis is frequently associated with infection of prosthetic heart valves, prosthetic orthopedic devices, and neurosurgical shunts. Penicillinase-resistant semisynthetic penicillins, such as methicillin, have been the therapeutic and prophylactic agents of choice for S epidermidis infection. However, more S epidermidis isolates are now resistant to methicillin and other penicillins. In our laboratory 41% of S epidermidis isolates were resistant to methici-lin. All of the methicillin-susceptible isolates and 82% of the methicillin-resistant isoates were susceptible to cephalothin. Cephalothin should replace methicillin as the prophylactic and therapeutic agent of choice in institutions with a high percentage of methicillin-resistant S epidermidis.

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CephalothinMethicillinMicrobial Sensitivity TestsPenicillin ResistanceStaphylococcusComparative StudyJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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W T Siebert, N Moreland, T W Williams. 1978. Methicillin-resistant Staphylococcus epidermidis.. https://doi.org/10.1097/00007611-197811000-00011

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