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PubMed · 2513488

Spectroscopic studies on IgG aggregate formation.

D A McCarthy·A F Drake
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Abstract

Spectroscopic techniques have been used to examine the effects of IgG of heating, irradiation by ultraviolet light and exposure to glutaraldehyde. Relatively few changes were observed in treated IgG which remained unaggregated but several significant size-dependent changes were observed in aggregated IgG. These results suggest that IgG aggregate formation by cross-linking with glutaraldehyde involves the least perturbation of the basis IgG structure, whereas aggregate formation by heating involves the most, with ultraviolet irradiation occupying an intermediate position.

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GlutaralHot TemperatureImmunoglobulin GProtein DenaturationSpectrometry, FluorescenceSpectrophotometry, UltravioletUltraviolet RaysJournal Article

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BibTeXRIS

D A McCarthy, A F Drake. 1989. Spectroscopic studies on IgG aggregate formation.. https://doi.org/10.1016/0161-5890(89)90144-2

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